EIC is a newly characterized syndrome affecting Labrador retrievers, especially dogs that are used for hunting and field trials. Five to fifteen minutes of strenuous exercise causes a dog to suffer from this condition and develops a ‘wobbly’ gait, which soon progresses to non-painful, flaccid paraparesis and a loss of control of the rear limbs. The episode may progress to all four limbs. Collapse episodes usually last for 5–10 min, and after 30 min there is often complete recovery, but episodes are occasionally fatal. The rectal temperature of dogs during an episode typically reaches 41.7 C (from a resting temperature of 39 C). Episodes occur more commonly in temperamental animals that are more excited under stress. However mild and moderate exercise (walking, swimming) are usually well tolerated and do not result in collapse.
Inheritance: autosomal recessive- read more
Mutation: DNM1 gene (Petterson et. al. 2008)
Genetic test: Disease or carrier can be identified by genetic testing at any age. The PCR method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs.
Disease control: read more
Affected breeds: Boykin Spaniel, Chesapeake Bay Retriever, Curly Coated Retriever, Clumber Spaniel, German Wirehaired Pointer, Labrador Retriever, Old English Sheepdog, Pembroke Welsh Corgi.
Sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.