Trapped neutrophil syndrome (TNS) is an autosomal recessive inherited neutropenia in the Border Collie breed. The disease, originally detected in Border Collies in Australia and New Zealand in the 1990's, is characterized by a marked reduction in numbers of neutrophils in peripheral blood and a hyperplasia of myeloid cells in bone marrow. Due to the severe neutropenia, affected dogs are consistently subject to life-threatening infections, resulting in premature death. However, a definitive diagnosis has been difficult because the original clinical characteristics except neutropenia have yet to be completely determined and the clinical features are often modified by chronic and recurrent infections.
Inheritance:autosomal recessive- read more
Mutation: VSP13B gene
Genetic test: Disease or carrier can be identified by genetic testing at any age. The PCR method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs.
Disease control: read more
Affected breeds: Border Collie
Sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.