Progressive retinal atrophy (PRA) is an inherited disease that occurs in many breeds of dogs and is reflected in various clinically indistinguishable forms. Progressive rod and cone degeneration in retina leads to progressive vision loss, which ends with total blindness. RCD4 is a form of PRA that was first described in Gordon Setters and later found in several other dog breeds. Gradual photoreceptor cell degeneration is typical for this form of the disease. Clinical signs usually become evident later in life (approx. 10 years of age).
Inheritance: Autosomal recessive - read more.
Mutation: C2orf71 gen
Genetic test: Genetic testing can identify affected or carrier animals at any age. The method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs.
Disease control: read more.
Affected breeds: Australian Cattle Dog, English Setter, Gordon Setter, Irish Setter, Polish Lowland Sheepdog, Small Munsterlander, Tibetan Terrier
Sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling are found here.