Polyneuropathy in Alaskan Malamute (AMPn) is one of several known canine hereditary neuropathies. Typical clinical signs are exercise intolerance, inspiratory stridor and pelvic limb ataxia. Gait abnormalities progress to paraparesis, in some cases deteriorating to tetraparesis. Many of the affected dogs have difficulties with standing and walking up stairs and eventually they collapse. First signs are usually noticed at 7 to 18 months of age.
Inheritance: autosomal recessive- read more
Mutation: NDRG1 gene
Genetic test: Disease or carrier can be identified by genetic testing at any age. The PCR method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs.
Disease control: read more
Affected breeds: Alaskan Malamute
Sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.