Progressive retinal atrophy (PRA) in dogs is a group of genetically heterogeneous inherited retinal disorders characterized by progressive degeneration and cell death of photoreceptors. X-linked progressive retinal atrophy (XL PRA) is an X-linked form of retinitis pigmentosa. Affected dogs have normal retina at birth. The first clinical symptoms appear at 6 months. Rod light receptors begin to appear irregularly damaged, later cone damage arises, and at an age of 4 years affected dogs are usually completely blind. Symptoms include progressive deterioration of central vision, mild photophobia, and moderate to high myopia.
Inheritance: X-linked recessive - read more
Mutation: RPGR gene
Genetic test: Disease or carrier can be identified by genetic testing at any age. The PCR method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs.
Affected breeds: Siberian Husky and Samoyed
Sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.