Glaucomas represent a group of diseases characterized by increased intraocular pressure, which causes retinal and optic disk destruction. Primary open angle glaucoma (POAG) in Beagles is inherited condition with typically increased eye pressure in both eyes. Symptoms become detectable between 8 and 16 months of age. As the pressure in the eye increases, the eyeball increases in size and becomes painful. Symptoms include sudden onset of pain, redness, tearing, squinting and blinking of the eye. If POAG is left untreated, increased pressure in the eye leads to optic nerve damage and gradual loss of vision. Most dogs exhibit luxation of the lens by 2,5 years of age.
Inheritance: autosomal recessive - read more
Mutation: ADAMTS10 gene
Genetic test: Disease or carrier can be identified by genetic testing at any age. The PCR method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs.
Disease control: read more
Affected breeds: Beagle
Sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.