Factor VII (FVII) is a vitamin K-dependent coagulation factor. It is synthesized in the liver and secreted into the circulation. It plays a major role in initiation of blood coagulation. Factor VII deficiency is associated with a bleeding tendency. Clinical signs in affected dogs include mild to severe bleeding after trauma or surgery.
Inheritance: autosomal recessive - read more
Mutation: Coagulation factor VII gene
Genetic test: Disease or carrier can be identified by genetic testing at any age. The PCR method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs.
Disease control: read more
Affected breeds: Airedale Terrier, Alaskan Klee Kai, Beagle, Giant Schnauzer and Scottish Deerhound
Sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.