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EVG, molekularna diagnostika
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Slovenia



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Description

Juvenile Laryngeal Paralysis & Polyneuropathy (JLPP) of Black Russian Terriers is a juvenile-onset neuronal disease.  As the longest nerves are often affected first, laryngeal paralysis is usually the first change that can be seen. Symptoms include difficulties in breathing and swallowing, which can cause serious pneumonia. Back legs are affected next. Dogs have difficulties when getting up and wobble as they walk. As the disease progresses, dogs with JLPP can become unable to walk at all. Other symptoms include ocular changes and sensory ataxia.

 

Inheritance: autosomal recessive- read more

Mutation: RAB3GAP1 gene

Genetic test: Disease or carrier can be identified by genetic testing at any age. The PCR method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs.

Disease control: read more

Affected breeds: Black Russian Terrier

Sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.

 

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