Hereditary glomerulopathy in Samoyed resembles hereditary nephritis (HN) in man. Human and dog hereditary nephritis describes a group of inherited glomerular diseases of collagen type IV. The disease is inherited as an X-linked dominant trait. Affected males and carrier females spontaneously develop proteinuria, but only males progress to renal failure.
The clinical course of HN in studied Samoyed dogs showed proteinuria developed at 2 to 3 months of age. In affected males a decreased growth rate was detected after 3 months, dogs became progressively thinner, and died from renal failure by 15 months of age. In contrast, the only change noted in the appearance of carrier females as they became older was failure to achieve normal weight.
Inheritance: X-linked dominant - read more
Mutation: COL4A5 gene
Genetic test: Disease or carrier can be identified by genetic testing at any age. The PCR method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs.
Affected breeds: Samoyed
Sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.