Neuroaxonal dystrophy (NAD) is an autosomal recessive genetic disease in Spanish water dogs and some other breeds. NAD is characterized by neurodegenerative pathology of the central and peripheral nervous system. Affected Spanish water dogs show various neurological deficits including gait abnormalities, behavioural deficits (dullness, nervousness…) and incontinence alone or in combination with uncontrolled defecation.
Hahn et. al. reported that NAD in Spanish water dogs is juvenile-onset. Neurological signs starting between six and eleven months of age. All affected dogs from the study were euthanized between 12 and 23 months of age.
Inheritance: autosomal recessive- read more
Mutation: TECPR2 gene
Genetic test: Disease or carrier can be identified by genetic testing at any age. The PCR method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs.
Disease control: read more
Affected breeds: Spanish water dogs
Sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.