Canine multiple system degeneration (CMSD) is a fatal autosomal recessive hereditary disease. First clinical signs develop at 3 to 6 months of age, and include cranial intention tremors, cerebellar ataxia, goose stepping gait and infrequent falls. Clinical signs become more severe with the disease progression and include frequent falling episodes, akinesia and severe postural instability. Affected dogs are usually euthanized by 1-2 years of age.
Inheritance: autosomal recessive- read more
Mutation: SERAC1 gene
Genetic test: Disease or carrier can be identified by genetic testing at any age. The PCR method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs.
Disease control: read more
Affected breeds: Chinese Crested dog, Kerry Blue Terrier
Sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.