Neonatal cerebellar cortical degeneration (NCCD) is a neurodegenerative disease found in several canine breeds including Beagles. NCCD in Beagle is characterised by clinical signs of cerebellar dysfunction, such as ataxia, crossing of legs, uncoordinated movement, loss of balance and tremor of the head and legs. First symptoms appear at around 3 weeks of age when puppies normally develop coordinated movement. The majority of puppies affected with NCCD are euthanized shortly after diagnosing the first signs of this disease.
Inheritance: autosomal recessive- read more
Mutation: SPTBN2 gene
Genetic test: Disease or carrier can be identified by genetic testing at any age. The PCR method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs.
Disease control: read more
Affected breeds: Beagle
Sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.