Alexander disease

Alexander disease is a progressive fatal neurodegenerative hereditary disorder, caused by astrocyte dysfunction. Astrocytes are specialized cells in the brain and spinal cord, which contain a specific protein called glial fibrillary acidic protein (GFAP). Mutation in GFAP gene is the most common cause of the disease. The age of affected dogs is usually less than 12 months. Clinical signs begin as incoordination, a head tilt, knuckling on limbs, issues with balance, nystagmus and an aversion to touch which later progress to ataxia, paresis in the hindlimbs and tetraparesis.

Inheritance: autosomal recessive - read more

Mutation: GFAP gene

Genetic test: The method used forgenetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.

Disease control: read more

DNA test sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.


52.00 €

  • You can order free sampling kit.
  • Only one sample is required for each animal, even if you order several tests.
  • Samples are stored for the option to order additional tests.
  • We offer expert assistance in interpreting the results.
Suitable for breeds
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