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Why DNA testing?

It enables:

  • Breeding of healthy animals
  • Breeding of animals with desired coat colour or type
  • Animal identification
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What we offer?

  • Performance of genetic tests according to the highest laboratory standards
  • Genetic counselling by veterinarians and PhD geneticists
  • Responsive and professional customer support
  • Breed specific panels
  • Discount schemes
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Simple and fast genetic testing

Determine hereditary predisposition for the development of specific diseases, characteristics and responses to therapy.

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Sample
For a genetic test we need cheek swabs or blood samples.
Analysis
Most genetic tests are completed within three to five working days.
Results
You will be informed about the results by e-mail, we will send you full reports by post.
Development of genetic tests
26.03.2021
Detecting new mutations and developing genetic tests is one of the first steps in controlling hereditary diseases in a dog population. Genetic tests allow us to avoid hereditary diseases with planned mating and even eradicate them through their informed use.   The development of a genetic test is done in several stages. Cooperation of breeders, veterinarians and researchers is essential for the development of a genetic test. Dog breeders can best track whether a problem that occurs in the dog line is hereditary. Most genetic diseases discovered in dogs to date are inherited autosomal recessively, in which both copies of the same gene must be defective for the genetic disease to develop - a copy received from the mother and a copy received from the father. You can read more about the mode of inheritance of genetic diseases HERE. It is very important for breeders to work with veterinarians, who can accurately describe the symptoms, link them to certain conditions and publish them in scientific journals. Thus, it often happens that several articles with symptoms of a genetic disease have been published before the development of the genetic test. In addition to the mode of inheritance and symptoms, it is also very important to know when the first signs of a genetic disease appear. Is it a genetic disease that occurs during embryonic development, immediately after birth, in the first year of life, or is it a late-onset disease.     When it is clear from the scientific publications or observations of breeders that certain symptoms are present due to a genetic disease, researchers search the entire genome and try to find causative mutation with the help of the latest genetic techniques. Mutations are permanent inherited changes in the genome caused by various factors called mutagens. Under the term mutation we often imagine something that is harmful to the individual, but this is not the case. Mutations can also be beneficial as they can give some individuals a new trait that improves their quality of life. For example, a mutation in hair length allows some breeds of dogs to live a better-quality life in cold conditions. Mutations that are beneficial to an individual are often preserved in nature. In the case of genetic diseases, we are talking about mutations that are harmful therefore we try to avoid them by correct breeding plans.   Detecting mutations alone can be quite time consuming, as research can take years. Mutations are sought throughout the dog’s genome, which is about 2.5 billion bases long. Genetic diseases can be monogenic, where the mutation is present in only one gene, or they can be polygenic, where several genes are involved in the development of a genetic disease. At the time of writing, more than 300 mutations associated with genetic diseases and traits of dogs are known. Most of known genetic diseases are monogenic, as much more studies and knowledge of the function of individual genes are needed to understand the functioning of polygenetic diseases.   When a new mutation for a particular genetic disease is known and well described, an article in scientific journal is published. The publication of the article is followed by the development of a genetic test that will be available to the general public.
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Storage and re-use of DNA samples of your dog
25.02.2021
In previous articles, we have described the entire path of the sample from sampling to results and their interpretation. If biological sample (swab, blood) was of high quality a lot of isolated DNA remains after the analysis, and it can be stored for reuse.   The DNA molecule is stable for a very long time under favourable conditions. Rapid advances in DNA technologies make it possible to obtain information from archaeological and paleontological remains. Thus, we can study the genetic links between extinct organisms and their modern relatives. Scientists can use the DNA molecule of organisms that lived before the advent of the Neanderthal. There are also studies on dog samples from more than 10,000 years ago.     The stability of DNA isolated in the laboratory is influenced by various factors from storage temperature, purity/the quality of the sample from which the DNA was isolated, the protocol used for isolation, the DNA sequence, and the exposure to light or UV radiation.   DNA is stored in a refrigerator at +4 °C for a short period of time, but in the case of good quality it is stable for several years in such conditions. Despite the good stability of DNA at +4 °C, it is better to store it at −20 °C or −80 °C for long-term storage. Sensitive DNA samples can be stored in liquid nitrogen at −196 °C. Such storage is used only for extremely sensitive samples (e.g. archaeological samples).   In our laboratory, DNA samples are stored at −20 °C for several years. And why do we keep DNA samples at all? DNA samples are stored so that they can be reused at the customer's request in the event of new discoveries and new genetic tests.   New technologies in the field of DNA enable very rapid detection of new mutations associated with various genetic diseases and physical traits (hair colour, tail length, etc.). At the time of writing, about 300 mutations are already known in dogs, but the number of these is rapidly increasing. Newly discovered mutation is followed by the development of a genetic test and the offering of this test on the market.   If you have sent a sample to our laboratory in the past, it is stored in most cases. In case you want to order an additional genetic test for the same animal, it is not necessary to send a new sample, as many different genetic tests can be performed from the existing sample. This will avoid the stress of taking the sample again, sending it, and doubting whether you took the sample correctly.
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