Canine multiple system degeneration (CMSD) is a fatal autosomal recessive hereditary disease. First clinical signs develop at 3 to 6 months of age, and include cranial intention tremors, cerebellar ataxia, goose stepping gait and infrequent falls. Clinical signs become more severe with the hereditary disease progression and include frequent falling episodes, akinesia, and severe postural instability. Affected dogs are usually euthanized by 1-2 years of age.
Inheritance: autosomal recessive - read more
Mutation: SERAC1 gene
Genetic test: The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers, and healthy dogs. DNA testing can be done at any age.
Disease control: read more
DNA test sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here