Chondrodysplasia is an autosomal recessive hereditary disease caused by dysfunction in the endochondral ossification process. Inherited chondrodysplasia usually occurs postnatal in purebred dogs. A form of chondrodysplasia was associated with ITGA10 gene which has an essential role in endochondral ossification. Affected dogs suffer from disproportionate short stature (dwarfism) of varying severity, which includes curved front limbs, carpal valgus, shortening of vertebral bodies, delayed ossification of carpal bones, increased metaphyseal width and flaring, undeveloped muscles of the pelvis due to severe hip dysplasia and abnormally short outer digits.

Inheritance: autosomal recessive - read more

Mutation: ITGA10 gene

Genetic test: The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.

Disease control: read more

DNA test sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.