Congenital ichthyoses comprise a heterogeneous group of genodermatoses characterized by abnormal desquamation over the whole body. Different genodermatoses can occur in different dog breeds. In American Bulldog, dermatological signs include a generalised scaling (epidermal hyperplasia), dermal inflammation, erythema of the rostral muzzle with scaling and paw pad hyperkeratosis. Dermatological signs can be visible at as early as a few weeks of age.

Inheritance: autosomal recessive - read more

Mutation: NIPAL4 gene

Genetic test: The method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. Testing can be done at any age.

Disease control: read more

Sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.