Disproportionate dwarfism is a hereditary autosomal recessive disease that belongs to the group of skeletal dysplasias. It is characterized by abnormal growth, development and remodelling of bones and cartilage. It involves relative length alterations of the limbs, changes in body proportions and typically manifests as disproportionate short stature in juvenile age. Radiographs of affected dogs reveal a decreased level of endochondral ossification in its growth plates and a premature closure of the distal ulnar physes. The symptoms become evident at 2 months of age and are often associated with health problems and represent animal welfare problems.

Inheritance: autosomal recessive - read more

Mutation: PRKG2 gene

Genetic test: The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.

Disease control: read more

DNA test sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.