Familiar nephropathy (FN) or Hereditary Nephropathy

Familiar Nephropathy (FN)is a hereditary disease that can be tested with a DNA test. Familiar nephropathy or hereditary nephropathy is an inherited disease causing kidney failure. The hereditary disease is the result of structural glomerular basement membrane (GBM) defects that alter mature kidney function. GBM is built of a network of collagen type IV molecules and mutation in any of collagen type IV gene can cause the disease. Affected dogs typically develop severe (end-stage) renal disease by the time they are 6 -24 months of age. The first clinical signs observed include excessive water consumption, excessive urine volume, reduced growth rate or weight loss, poor hair coat quality, vomiting and reduced appetite.

Inheritance: autosomal recessive - read more

Mutation:  COL4A4  gene

Genetic test: The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.

Disease control: read more

DNA test sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.


54.00 €

  • You can order free sampling kit.
  • Only one sample is required for each animal, even if you order several tests.
  • Samples are stored for the option to order additional tests.
  • We offer expert assistance in interpreting the results.
It appears you are using an older browser we don't support fully! For better and user friendly experience use one of the following internet browsers or update your current browser to the latest version.