Elliptocytosis is an autosomal disorder of the red blood cells (RBC), which assume an elongated elliptical shape rather than typical round shape. The condition is diverse, ranging from asymptomatic cases to severe haemolysis. Clinical signs include severe haemolytic anaemia, loss of the normal elastic recoil property of RBCs within the peripheral circulation, resulting in their distinctive elliptical shape. This disturbance is caused because the α-spectrin cannot associate in dimeric form with the β-spectrin, disrupting the membrane cytoskeleton.

Inheritance: autosomal dominant

Mutation: SPTB gene

Genetic test: The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.

DNA test sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.