Inherited Myopathy in Great Danes (IMGD)

Inherited Myopathy in Great Danes (IMGD) is a hereditary disease that can be tested with a DNA test. Characteristic signs of centronuclear myopathies include generalized muscle weakness, atrophy, predominance of type I fibres, and aberrant cell positioning of nuclei and mitochondria. In Great Danes generalized muscle atrophy, exercise intolerance, exercise-induced tremor and muscle wasting characterize the disease. This hereditary disease typically starts before 10 months of age, is highly progressive, and most of the affected dogs are euthanized before 18 months of age due to severe debilitating muscle weakness. 

Inheritance: autosomal recessive - read more

Mutation: BIN1 gene

Genetic test: The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.

Disease control: read more

DNA test sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.


54.00 €

  • You can order free sampling kit.
  • Only one sample is required for each animal, even if you order several tests.
  • Samples are stored for the option to order additional tests.
  • We offer expert assistance in interpreting the results.
Suitable for breeds
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