Limb grindle muscular dystrophy type 3 (LGMD-R3) is an autosomal recessive disease described in Miniature Dachshund Dogs. Clinical signs include generalized weakness, exercise intolerance, stiff gait, difficulty swallowing and repetitive pneumonia. The symptoms of affected dogs appear at around 6 months of age and slowly progress over the next several years. They also include a consistent high levels of the muscle enzyme creatin kinase in the blood and excess myoglobin in the urine, which indicates breakdown of the muscles. The affected dogs usually have to be euthanised due to progression of the disease.

Inheritance: autosomal recessive - read more

Mutation: SGCA gene

Genetic test: The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.

Disease control: read more

DNA test sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.