Globoid cell leukodystrophy (GLD), or Krabbe disease, is a severe disorder resulting from a deficiency of galactocerebrosidase (GALC) activity. GALC is responsible for the lysosomal catabolism of certain galactolipids. Clinically, the symptoms appear between 1 and 3 months of age. Weakness of the limbs and tremors appear first, followed by muscular atrophy and neurological degeneration. Affected dogs may live until 8 or 9 months of age, when the symptoms become so severe that the dog is usually euthanized.

Inheritance: autosomal recessive - read more

Mutation: GALC gene

Genetic test: The method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. Testing can be done at any age.

Disease control: read more

Sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.