Shaking puppy syndrome (SPS) or hypomyelination syndrome (HS) is a disease characterized by an abnormally low amount of myelination or its absence in the axons of the central nervous system (CNS). SPS has been described in people and in dogs including Dalmatian, Bernese Mountain dog, Chow-Chow and Weimaraner breeds. The cause of SPS is not known in all breeds. A causative mutation in the gene in Weimaraner breeds has been reported. In Weimaraner symptoms occur between 12 and 14 days of age. Dogs develop a generalized tremor that can vary in severity. Despite the tremor, symptoms disappear when puppies are at rest or asleep. After 3 to 4 months, the tremor diminishes, though some animals retain a fine tremor of the hind limbs.

Inheritance: autosomal recessive - read more

Mutation: FNIP2 gene

Genetic test: The method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. Testing can be done at any age.

Disease control: read more

Sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.