Hypophosphatasia (HPP) is a rare canine autosomal recessive disease affecting bone and cartilage tissues. The symptoms include skeletal hypomineralisation, growth retardation, short stature, hypotonia, fractures, seizures and movement difficulties, meanwhile the cognition remains unharmed. Affected individuals can be stillborn or they develop mild to aggressive symptoms in the adulthood.

Inheritance: autosomal recessive - read more

Mutation: ALPL gene

Genetic test: The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.

Disease control: read more

DNA test sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.