Congenital ichthyosis (ICT-A)is a hereditary disease which can be tested with a DNA test. Congenital ichthyoses comprise a heterogeneous group of genodermatoses characterized by abnormal desquamation over the whole body. Different genodermatoses can occur in different dog breeds. In Golden Retrievers, dermatological signs include a mild, moderate or severe generalised scaling, initially with small to large whitish scales that progress to blackish scales. The ventral glabrous skin can be hyperpigmented and rough. Dermatological signs can be visible at as early as a few weeks of age. To date, 2 different mutations in the PNPLA1 and ABHD5 genes causing ICT have been discovered in golden retriever.

Inheritance: autosomal recessive - read more

Mutation: ABHD5 gene

Genetic test: The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.

Disease control: read more

DNA test sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.