Juvenile myoclonic epilepsy (JME) is a hereditary disease which can be tested with a DNA test. Juvenile myoclonic epilepsy (JME) is a breed-specific generalized myoclonic epilepsy with an early onset. It occurs in Rhodesian Ridgeback breed.  Thishereditary disease is characterized by myoclonic seizures, which cause rapid uncontrolled muscle jerks and twitches. Muscle jerks usually affect proximal limb, trunk, head and face. Seizures can occur at any time, most commonly when the dogs are sleeping or resting. Photosensitivity has also been noticed in affected dogs. This hereditary disease appears early in life, typical between 6 weeks to 18 months of age.

Inheritance: autosomal recessive - read more

Mutation: DIRAS1 gene

Genetic test: The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.

Disease control: read more

DNA test sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.