Canine hereditary multifocal renal cystadenocarcinoma and nodular dermatofibrosis (RCND) is inherited genetic predisposition causing kidney, dermal and uterine cancer in German Shepherd Dogs. The syndrome is characterized by bilateral, multifocal tumours in kidneys and numerous firm nodules, consisting of dense collagen fibres in the skin and subcutis. In female dogs uterine cancer (benign smooth muscle tumour) is also present. Symptoms of the kidney cancer include blood in urine, polydipsia (excessive thirst or excess drinking), progressive weight loss, anorexia, vomiting, and respiratory distress.

Inheritance: autosomal dominant - read more

Mutation: FLCN gene

Genetic test: The method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. Testing can be done at any age.

Sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.