Ligneous membranitis is an autosomal recessive disorder also known as Plasminogen deficiency and ligneous conjunctivitis. It is a rare chronic inflammatory condition of the mucous membranes associated with plasminogen deficiency. The clinical signs of affected dogs occur at around 2 months of age and include redness of the conjunctiva with persistent membranes having ligneous (wood-like) membranes on the eyes. Other clinical signs include increased upper respiratory tract noise, nasal discharge and lymphadenopathy. The affected dogs usually have to be euthanized due to progression of the disease.

Inheritance: autosomal recessive - read more

Mutation: PLG gene

Genetic test: The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.

Disease control: read more

DNA test sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.