Exfoliative cutaneous lupus erythematosus is one of four types of lupus erythematosus. This dog-specific form of chronic cutaneous lupus erythematosus (CLE) is classified as an autoimmune skin disease causing an inflammatory response of the basement membrane zone of the skin. Consequently, affected dogs suffer from scaling and crusty red lesions first on the face, ears and back that then spread to their chest, abdomen and legs. With the progression of the disease hair loss and loss of skin pigmentation, erythema, swollen lymph nodes, secondary infections and infertility is also common. The condition often causes swelling of the joints where dogs become stiff, lame and show a hunched stance. The disease can also become systemic with the involvement of other organs where in later stages dogs may develop lupus nephritis. ECLE commonly affects breeds of German Shorthaired Pointer, German Longhaired Pointer and Vizsla, where it usually develops before 10 months of age. As a result of severe symptoms affected dogs have a shorter life span, where they usually have to be euthanized.

Inheritance: autosomal recessive - read more

Mutation: UNC93B1 gene

Genetic test: The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.

Disease control: read more

DNA test sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.