Macrothrombocytopenia (MTC) is an asymptomatic inherited disorder in which dog's platelets are abnormally large and low in number. The main signs of the disease are enlarged platelets and their reduced number. Affected dogs are not prone to bleeding presumably due to the presence of a normal circulating platelet mass measured in affected dogs. In addition, many veterinarians mis-diagnose macrothrombocytopenia with either immune-mediated thrombocytopenia (IMT) or immune-mediated hemolytic anemia (IMHA).

Inheritance: autosomal recessive - read more

Mutation: TUBB1 gene

Genetic test: The method used forgenetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.

Disease control: read more

DNA test sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.