Persistent Müllerian Duct Syndrome (PMDS) is a sex-limited autosomal recessive disorder, characterized by the presence of Müllerian duct derivatives in otherwise phenotypical normal male dogs. PMDS male dogs have a normal male karyotype (78, XY) but develop a complete bicornuate uterus, bilateral oviducts, uterine body, a cervix, and the cranial portion of the vagina (upper vagina). Approximately 50% of affected dogs are unilaterally or bilaterally cryptorchid. Testing for the mutation prior to breeding is recommended, because affected dogs with scrotal testes are fertile but they transmit mutation to their offspring’s.
Inheritance: autosomal recessive - read more
Mutation: AMHR2 gene
Genetic test: The method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. Testing can be done at any age.
Disease control: read more
Sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.