Polyneuropathy in Alaskan Malamute (AMPn) is one of several known canine hereditary neuropathies. Typical clinical signs are exercise intolerance, inspiratory stridor and pelvic limb ataxia. Gait abnormalities progress to paraparesis, in some cases deteriorating to tetraparesis. Many of the affected dogs have difficulties with standing and walking up stairs and eventually they collapse. First signs are usually noticed at 7 to 18 months of age.
Inheritance: autosomal recessive - read more
Mutation: NDRG1 gene
Genetic test: The method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. Testing can be done at any age.
Disease control: read more
Sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.