Factor XII is a coagulation factor important in cardiovascular processes as a modulator of vascular permeability, initiator of blood coagulation pathway and inflammatory processes. Feline factor XII deficiency also known as Hageman deficiency is a common hereditary trait with an autosomal recessive mode of inheritance. It is naturally occurring in domestic cats and other breeds such as Maine Coon, Persian, Turkish Van, Bengal and Russian Blue. The disease manifests as a prolonged clotting time with no signs of abnormal bleeding. Due to mostly asymptomatic cases, it is generally considered an incidental clinical finding. A genetic mutation associated with the disease causes decreased secretion of FXII protein from cells. Homozygous cats have less than 10% of normal FXII activity, whereas heterozygotes have more moderate FXII deficiency.

Inheritance: autosomal recessive - read more

Mutation:  F12 gene

Genetic test: The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age. 

Disease control: read more

DNA test sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.