Succinic semialdehyde dehydrogenase deficiency (SSADHD)

Succinic semialdehyde dehydrogenase deficiency (SSADHD) is an inherited genetic disease caused by inefficient metabolic breakdown of y-aminobutyric acid (GABA). The enzyme succinic semialdehyde dehydrogenase has important role in part of the metabolism of the neurotransmitter GABA. First clinical signs of affected puppies usually start at the age of 6-10 weeks. Neurological abnormalities may include seizures, change in behaviour, mild generalized ataxia, atrophy of the cerebellar cortex with vacuolization, lethargy, increased levels of gamma-hydroxybutyric acid and increased levels of succinic semialdehyde.

Inheritance: autosomal recessive - read more

Mutation: ALDH5A1 gene

Genetic test: The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.

Disease control: read more

DNA test sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.

New

Price:

52.00 €

  • You can order free sampling kit.
  • Only one sample is required for each animal, even if you order several tests.
  • Samples are stored for the option to order additional tests.
  • We offer expert assistance in interpreting the results.
Suitable for breeds
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