Primary open angle glaucoma (POAG) is an optic neuropathy disorder with an autosomal recessive inheritance, characterized by death of retinal ganglion cells and damage of the optic nerve that can lead to irreversible blindness. It is commonly diagnosed in middle-aged or elderly dogs, when it starts to affect the dog’s visual capabilities, however the actual disease onset may be much earlier. Clinical signs of affected dogs include eye irritation, elevated intraocular pressure, affected peripheral vision, secondary subluxation of the lenses and lastly loss of vision. The success of any glaucoma treatment depends upon how early the condition is diagnosed.

Inheritance: autosomal recessive - read more

Mutation: ADAMTS10 gene

Genetic test: The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.

Disease control: read more

DNA test sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.