Canine progressive retinal atrophies (PRA) are genetically heterogeneous diseases caused by several mutations and affect more than 100 dog breeds. The disease primarily affects photoreceptors initially, leading to night blindness. As the disease progresses, impairment of daylight vision and eventually complete blindness occurs. In Giant Schnauzer, the clinical symptoms occur at approximately four years of age. A missense variant in NECAP1 gene has been identified, suggesting a novel form of PRA in Giant Schnauzer.

Inheritance: autosomal recessive - read more

Mutation: NECAP1 gene

Genetic test: The method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. Testing can be done at any age.

Disease control: read more

Sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.