Cleft palate is a genetically inherited craniofacial birth defect affecting Nova Scotia Duck Tolling Retrievers, amongst other breeds. The defect is caused by a disruption in the secondary palate development, which is the bony structure separating the nose from the mouth, resulting in a hole or cleft in the palate. The cleft palate is accompanied by an uneven alignment of the upper and lower jaw, shorter mandibles, poorly developed or absent nasal septum and posteriorly placed tongue. The affected dogs show difficulties in feeding, with a high risk of aspiration pneumonia due to food entering the cleft. The disorder manifests itself during early stages of embryonic development. 

Inheritance: autosomal recessive - read more

Mutation:  DLX6 gene

Genetic test: The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age. 

Disease control: read more

DNA test sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.