Shaking puppy syndrome is an inherited genetic defect that results in delayed myelination of the central nervous system. This disorder is caused by lack of myelin, which is a white substance that surrounds the axon of nerve cells and has important role in functioning of the nervous system. The disease is a rare neurological disorder that affects dogs of certain breeds. The first clinical symptoms are characterized by a severe tremor, which is usually appearing at twelve days of age followed by late onset convulsions and, under natural conditions, an early death by about 3-4 months of age. Clinical signs of affected puppies may also include difficulties with keeping balance, coordinating movements and maintaining balance in space.

Inheritance: X-linked recessive - read more

Mutation: PLP1 gene

Genetic test: The method used forgenetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.

DNA test sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.