Progressive retinal atrophy (PRA-XL, X-linked progressive retinal atrophy) is a hereditary disease which can be tested with a DNA test. Progressive retinal atrophy (PRA) in dogs is a group of genetically heterogeneous inherited retinal disorders characterized by progressive degeneration and cell death of photoreceptors. X-linked progressive retinal atrophy (XL PRA) is an X-linked form of retinitis pigmentosa. Affected dogs have normal retina at birth. The first clinical symptoms appear at 6 months. Rod light receptors begin to appear irregularly damaged, later cone damage arises, and at an age of 4 years affected dogs are usually completely blind. Symptoms include progressive deterioration of central vision, mild photophobia, and moderate to high myopia.
Inheritance: X-linked recessive - read more
Mutation: RPGR gene
Genetic test: The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.
DNA test sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.