Acatalasemia is a genetic disease that affects humans and animals, including dogs. The disease is characterised by the absence or little amount of the enzyme catalase, which is responsible for breaking down hydrogen peroxide in cells. The primary function of the enzyme is to safeguard the tissues from reactive oxygen species. When there is an excess amount of hydrogen peroxide, it can harm cells and tissues by causing a process called oxidative damage. The enzyme catalase is typically present in red blood cells, mucous membranes, liver, muscles and skin. Clinical symptoms of acatalasemia in dogs may include eating or drinking difficulties, weight loss and oral bleeding which are the consequence of gum ulcerationprogressing to gangrene.

Inheritance: autosomal recessive - read more

Mutation: CAT gene

Genetic test: The method used forgenetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.

Disease control: read more

DNA test sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.