Hereditary deafness is widely spread among multiple dog breeds with differing age of onset, diverse clinical symptoms and various genetic causes. Hereditary hearing loss described in Rottweilers is identified as the LOXHD1 variant. This variant is caused by a mutation in the gene responsible for the normal function of the mechanosensory hair cells in the cochlea (part of the inner ear containing the sensory organ for hearing), resulting in the deterioration of the inner ear hairs and deafness. This variant is specific for the Rottweiler breed, but it can also be found in mixed-breed dogs with Rottweiler ancestry. The hearing loss usually becomes evident at birth or in the first few weeks of life, progressing into total bilateral deafness. The affected dogs show no other clinical symptoms.
Inheritance: autosomal recessive - read more
Mutation: LOXHD1 gene
Genetic test: The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.
Disease control: read more
DNA test sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.