Footpad hyperkeratosis is an autosomal recessive disorder, characterized by severe footpad hyperkeratosis. The clinical signs occur at around 8 weeks of age and include dry, thick and rapidly growing footpads, footpad lesions, atopic dermatitis, recurrent bacterial skin and ear infections, crusted hyperkeratotic plaques at sites of infection and severe discomfort. These signs cause significant discomfort and require regular trimming of the footpads under anaesthesia, applications of moisturizers, as well as pain management and treatment for pruritus and infections.

Inheritance: autosomal recessive - read more

Mutation: DSG1 gene

Genetic test: The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.

Disease control: read more

DNA test sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.