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Disease control- autosomal recessive inheritence

Regarding to the presence of mutations dogs are classified into three groups:

 

  • Affected (mut/mut)- both alleles carry mutation, disease is clinically  expressed
  • Carrier (mut/wt)- one of two alleles carry mutation, disease is not clinically expressed
  • Wild type (wt/wt)- mutation is not detected, normal genotype, healthy animal

 

For each group different breeding strategies can be applied in order to control the spread of the disease. Breeding with affected or carrier dogs should be avoided. In the case that the owner holds particularly valuable dogwhich carry the mutation, such dog should be bred with healthy/unaffected individual. In the case where an affected dog was bred with healthy individual all animals of the offspring are carriers therefore genetic testing is not necessary (Figure 1). When first generation of dogs is bred again with healthy/unaffected animal 50% of the second generation of dogs is free of mutations (Figure 2). If two carrier animals are bred 25% of the offspring is healthy/unaffected (Figure 3). Second generation should be tested and only dogs which do not carry mutation are used for further breeding. 

 

 

  Affected
Wild type Allele mut mut
wt wt/mut (carrier) wt/mut (carrier)
wt wt/mut (carrier) wt/mut (carrier)

Figure 1

 

 

  Carrier
Wild type Allele wt mut
wt wt/wt (wild type) wt/mut (carrier)
wt wt/wt (wild type) wt/mut (carrier)

Figure 2

 

  Carrier
Carrier Allele wt mut
wt wt/wt (wild type) wt/mut (carrier)
mut wt/mut (carrier) mut/mut (affected)

Figure 3